DoxyPEP

• It is a pill with an antibiotic called doxycycline
• You take it after you have sex without a condom
• It can help stop you getting syphilis and chlamydia
• It is not always a replacement for condoms. It is an extra choice to help stop you from developing syphilis and chlamydia only.

DoxyPEP is recommended for:

• Gay men, bisexual men and other men who have sex with men
• Trans women
• Especially if you are at a higher chance of getting syphilis

You might have a higher chance if:

• You have had an STI like syphilis or chlamydia in the last year
• You have had more than one new partner in the last few months
• You have sex in groups or use drugs for sex (chemsex)
• Having sex is part of your job

• How much? Take 2 pills (2x 100mg) at the same time
• When? Take it within 3 days (72 hours) after sex without a condom. Sooner is better!
• How often? Never take more than one dose (2 pills) in a single day

For example, if you have sex on Friday and Saturday, you can take one dose on Sunday to cover both days

• It works very well. It can stop about 8 out of 10 syphilis and chlamydia infections
• It can make you feel less worried about getting STIs
• It gives you more control over your health

• It doesn't work for everything. It doesn't stop HIV. You still need PrEP or condoms to prevent HIV transmission if your HIV positive partner is not on effective treatment
• It is not effective at preventing other STIs
• Testing is still important! You should still get tested for STIs regularly. DoxyPEP is not 100% so you could still get an infection
• Side effects: some people get a sore stomach, feel sick or gete sunburned more easily. This is usually mild.